|Immunogen||:||PAP purified from seminal fluid|
|Protocol||:||30 min @ RT|
|Control tissue||:||Prostate carcinoma tissue|
Prostate acid phosphatase (PAP) is a 100 kD glycoprotein present in high concentration in the prostate gland and its secretions. PAP is measured clinically because its level often rises in the serum in cases of prostatic carcinoma. By immunohistochemical analysis PAP has been found concentrated within the large secretory vacuoles of the supra nuclear portion of the prostatic columnar epithelial cell. In hyperplastic prostates and in benign prostatic tissue adjacent to the prostatic carcinoma, PAP activity is limited to the acinar or ductal columnar epithelial cells and adjacent luminal content. PAP reactivity
in an extraprostatic tumor is an accurate and sensitive indicator of metastatic prostatic carcinoma.
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