E-Cadherin
Membranous positivity of E-Cadherin on breast carcinoma stained using DAB chromogen
| Clone | : | 36 |
| Isotype | : | IgG1 |
| Immunogen | : | C-terminal peptide of human E-cadherin |
| Source | : | Mouse |
| Specificity | : | E-cadherin |
| Protocol | : | 30 min @ RT |
| Tissue type | : | FFPE |
| Control tissue | : | BREAST CARCINOMA |
| Pretreatment | : | AR-10 |
| Intended Use | : | IVD |
E-Cadherin (123-kD) is a cell surface glycoprotein responsible for Ca2+-dependent intercellular adhesion between epithelial cells; it is also called uvomorulin, L-CAM, cell-CAM 120/80 or Arc-1. Alterations in the cell-cell adhesion mechanism mediated by E-Cadherin which is lightly associated with alpha catenin may have implications in the metastatic potential of prostate cancer. E-Cadherin may also play a role in adhesion of dendritic epidermal T cells to keratinocytes. Clone 36 may be used to investigate the process of tumor invasion. This antibody stains E-Cadherin in the membrane of positive cells.
