|Immunogen||:||C-terminal peptide of human E-cadherin|
|Protocol||:||30 min @ RT|
|Control tissue||:||BREAST CARCINOMA|
E-Cadherin (123-kD) is a cell surface glycoprotein responsible for Ca2+-dependent intercellular adhesion between epithelial cells; it is also called uvomorulin, L-CAM, cell-CAM 120/80 or Arc-1. Alterations in the cell-cell adhesion mechanism mediated by E-Cadherin which is lightly associated with alpha catenin may have implications in the metastatic potential of prostate cancer. E-Cadherin may also play a role in adhesion of dendritic epidermal T cells to keratinocytes. Clone 36 may be used to investigate the process of tumor invasion. This antibody stains E-Cadherin in the membrane of positive cells.
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