Blood Group Antigen Lewis B
Intestine stained with Anti-Blood
group Lewis B antibody using AEC
chromoge
| Clone | : | 2-25LE |
| Isotype | : | IgG1 |
| Immunogen | : | Mucin isolated from ovarian cyst fluid |
| Source | : | Mouse |
| Specificity | : | Blood group antigen Lewis B |
| Protocol | : | 30 min @ RT |
| Tissue type | : | FFPE |
| Control tissue | : | STOMACH |
| Pretreatment | : | None |
| Intended Use | : | IVD |
Lewis blood group antigens are carbohydrate moieties structurally integrated in mucous secretions. Lewis antigen system alterations have been described in gastric carcinoma and associated lesions. Anomalous expression of Lewis B antigen has been found in some non-secretory gastric carcinomas and colorectal cancers. This antibody will stain Lewis B antigen in formalin-fixed, paraffin-embedded tissues. A panel of antibodies to Lewis antigens, including Lewis A, Lewis B and sialylated Lewis A, is useful in the immunopathological analysis of gastric cancers. Monoclonal antibody 2-25LE detects Lewis B antigen in cultured cells and tissue sections using immunohistochemistry and will react with the immunogen in ELISA assays. This antibody stains blood group antigen Lewis B.
