|Immunogen||:||A synthetic peptide corresponding to residues on the C-terminus of human CD38 was used as an immunogen.|
|Protocol||:||30 min @ RT|
|Control tissue||:||Lymph node tissue|
|Pretreatment||:||AR Citra Plus|
CD38 or cyclic ADP ribose hydrolase is a multifunctional ectoenzyme that regulates the cellular levels of nictotinamide adenine dinucleotide (NAD). It also acts as a second messenger enzyme, regulating the release of intracellular Ca2+ through cyclic ADP ribose. It is expressed at high levels on the surface of peripheral B-lineage cells, and at low density on germinal center B cells. It is also expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes that are mostly TCR+, CD4-, CD8-. CD38 also functions in cell adhesion, signal transduction, and calcium signaling. It is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma and neuroblastoma. CD38 is useful in subtyping of lymphomas and leukemias.
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