Glial Fibrillary Acidic Protein (GFAP)
Astrocytes and other acidic fibers in cerebrum stained with anti-GFAP using DAB chromogen
| Clone | : | GA-5 |
| Isotype | : | IgG1 |
| Immunogen | : | GFAP isolated from porcine spinal cord |
| Source | : | Mouse |
| Specificity | : | Glial fibrillary acidic protein (GFAP) |
| Protocol | : | 30 min @ RT |
| Tissue type | : | FFPE |
| Control tissue | : | CEREBELLUM |
| Pretreatment | : | None |
| Intended Use | : | IVD |
Glial fibrillary acidic protein (GFAP) is the subunit of the glial specific "intermediate" filament that include desmin filaments in smooth muscle, vimentin filaments in cultured fibroblasts, keratin filaments in epithelium and neurofilaments in neural cells. GFAP is a major product of astrocytic differentiation. Compared with special stains currently used to identify an astroglial component in brain tumors, GFAP staining is more sensitive. Further, the immunohistochemical staining method is useful in demonstrating reactive astrocytes, whether secondary to a brain tumor or to any other neuro-pathological condition.This antibody stains human GFAP in positive astrocytes and other positive cells.
