|Immunogen||:||IgD isolated from a pool of normal human sera.|
|Protocol||:||30 min @ RT|
Immunoglobulin (Ig) heavy chains are classified in five classes, namely IgA, IgD, IgE, IgG and IgM, on basis of charge, carbohydrate content, size and amino acid composition. IgD is expressed on mature B cells and may be used to classify B cell neoplasms. Mantle zone B-cells in primary follicles and those outlining the germinal centers of secondary follicles are seen to be positive for IgD expression. Thus, this antibody could be used to detect changes in nodal architecture. It also may be used to detect the expanded follicular structures of progressive transformation of germinal center (PTGC), which are composed largely of IgD+ mantle zone B-cells. It is used along with IgM as a marker to identify marginal zone lymphomas.
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