Tyrosinase
Melanoma tissue stained with Anti-Tyrosinase using AEC as chromogen.
| Clone | : | Ty/G5 |
| Isotype | : | IgG |
| Immunogen | : | Human Tyrosinase |
| Source | : | Mouse |
| Specificity | : | Tyrosinase |
| Protocol | : | 30 min @ RT |
| Tissue type | : | FFPE |
| Control tissue | : | Melanoma Tissue |
| Pretreatment | : | EZ-AR™1 |
| Intended Use | : | IVD |
Tyrosinase is an enzyme that catalyses the oxidation of phenols (such as tyrosine) and is widespread in plants and animals. Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation. The gene for Tyrosinase is regulated by the Microphthalmia- associated transcription factor. A mutation in the tyrosinase gene resulting in impaired tyrosinase production results in type I oculocutaneous albinism, a hereditary disease that one in every 17,000 person has in the US. Anti-Tyrosinase has been found to be quite specific for melanotic lesions such as malignant melanoma, and melanotic neurofibroma. Essentially no carcinomas express this marker.
