|Protocol||:||30 min @ RT|
|Control tissue||:||Melanoma Tissue|
Tyrosinase is an enzyme that catalyses the oxidation of phenols (such as tyrosine) and is widespread in plants and animals. Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation. The gene for Tyrosinase is regulated by the Microphthalmia- associated transcription factor. A mutation in the tyrosinase gene resulting in impaired tyrosinase production results in type I oculocutaneous albinism, a hereditary disease that one in every 17,000 person has in the US. Anti-Tyrosinase has been found to be quite specific for melanotic lesions such as malignant melanoma, and melanotic neurofibroma. Essentially no carcinomas express this marker.
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