Xmatrx Infinity
i6000 Infinity
EZ - Retriever
Xmatrx Infinity is designed for the life science research, and drug discovery & development. The system adapts and completely automates any manual protocols including denaturation, hybridization, stringency washes, counter stain e.g. DAPI, and final coverslip.
Multiplexing of NAD and IHC in the same specimen, a hallmark of the system facilitates co-detection of multiple biomarkers while preserving the tissue morphology and spatial information. The in situ quantitative gene-expression profiling enables target identification, prioritization, selection and validation.
Multiplexing of NAD and IHC in the same specimen, a hallmark of the system facilitates co-detection of multiple biomarkers while preserving the tissue morphology and spatial information. The in situ quantitative gene-expression profiling enables target identification, prioritization, selection and validation.
Key Benefits
Accelerate the Pace of Discovery
- Simultaneous optimization of up to forty parameters in a single run
- Co-detection of multiple nucleic acid and protein biomarkers
- Multiplexing of single or multiple specimens on a single slide
- Multi-format specimen analysis : Tissues - frozen or FFPE |Cell preparations | Smears
- Fine needle aspirates (FNA) and many more
Flexibility and Control
Enables complete automation of any slide based assays:
- IHC | IF | ISH | CISH | FISH
- Co-detection and multiplexing of nucleic acid and protein biomarkers
- In situ PCR | miRNA | CTC
- Flexibility and Control
Ease of Use
- Real time slide map
- Intelligent bulk fluidics system
- Efficient waste management system
- Reports for inventory management and regulatory compliance
FISH
HER-2 DNA
HER-2 gene amplification detected in breast carcinoma
HER-2 mRNA
HER-2 mRNA expression in SK-BR3 cells
HPV16 DNA
HPV16 DNA detected in cervical carcinoma
CTC
Visualization of CD45 and Cytokeratin (CK)
Fluorescence labeled anti-CD45 and anti-CK in CTC (Circulating Tumor Cells)
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Circulating Tumor cells in blood
Circulating tumor cells detected in peripheral blood of a patient with metastatic cancer
IHC
Visualization of p16 in Cervical Carcinoma
Cervical carcinoma tissue stained with anti–p16.
Visualization of Pin4 in Prostate Tissue
Prostate tissue stained with anti-Pin4
Double Staining for TTF1 and CK5/CK6
Lung tissue stained with TTFI and CK5/6 using Double Staining method.
In situ PCR
Detection of HPV16 in Cervical Carcinoma
Detection of HPV 16 in cervical carcinoma by in situ PCR (10 cycles) followed by visualization of amplicons with DAB.
Negative control
Negative control stained using in situ PCR
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