Actin, Smooth Muscle
Small intestine stained with Anti-
Smooth Muscle Actin using DAB
chromogen
| Clone | : | 1A4 |
| Isotype | : | IgG2a |
| Immunogen | : | Synthetic NH2 terminal decapeptide of alpha smooth muscle actin coupled to keyhole limpet hemocyanin (KLH) |
| Source | : | Mouse |
| Specificity | : | Alpha Smooth Muscle Actin |
| Protocol | : | 30 min @ RT |
| Tissue type | : | FFPE |
| Control tissue | : | COLON |
| Pretreatment | : | None |
| Intended Use | : | IVD |
Actin is one of two major cytoskeletal proteins. The antibody can be used to identify smooth muscle tumors. It stains leiomyomas and leiomyosarcomas but does not stain carcinomas, melanomas, lymphomas or non-smooth muscle sarcomas. It stains the muscularis and muscularis mucosa of the gastrointestinal tract, the uterine myometrium, medial layer of blood vessels, the mesenchymal components of the prostate, and myoepithelial cells of salivary glands and other organs. The antibody does not stain striated muscle such as skeletal and cardiac muscle, endothelium, connective tissue, epithelium or nerve. This antibody stains positive in cytoplasm of smooth muscle cells.
