Alpha-1-Antitrypsin

Alpha-1-Antitrypsin (AAT) is a 54 kD glycoprotein. Most of the anti-proteolytic enzyme activity of serum resides in this fraction. It is also found in lymph, mucus, saliva, synovial fluid, gastrointestinal tract secretions, semen, amniotic fluid and colostrum. It is a useful marker for benign and malignant hepatic neoplasms, endodermal sinus tumors, and for histiocytic differentiation in benign and malignant fibrous histiocytomas. This antibody has been absorbed with fractionated human plasma to remove contaminating antibodies. When tested by crossed immunoelectrophoresis against human plasma, a single preciptin line was observed.