Alpha-Fetoprotein (AFP)
Hepatocellular carcinoma stained
with Anti-AFP using AEC chromogen
| Clone | : | C3 |
| Isotype | : | IgG2a |
| Immunogen | : | Affinity-purified human Alpha-Fetoprotein |
| Source | : | Mouse |
| Specificity | : | Alpha-fetoprotein |
| Protocol | : | 30 min @ RT |
| Tissue type | : | FFPE |
| Control tissue | : | HEPATOCELLULAR CARCINOMA |
| Pretreatment | : | None |
| Intended Use | : | IVD |
Alpha-Fetoprotein (AFP) is a 64 kD tumor-associated embryonal antigen produced by fetal liver, hepatoma, yolk sac, and several germ cell tumors of testicular and ovarian origin. Of the germ cell tumors, only embryonal carcinoma and endodermal sinus tumors stain positive for AFP and not teratomas. The positive results are useful in distinguishing embryonal carcinoma from seminoma. AFP is present in the mononuclear embryonal carcinoma cell and in the intracellular or extracellular hyaline droplets. This antibody stains positive for alpha fetoprotein in the cytoplasm of positive cells.
