Cytokeratin Cocktail
Skin tissue stained with Cytokeratin cocktail AE1 & AE3 using AEC chromogen
| Clone | : | AE1 and AE3 |
| Isotype | : | IgG1 |
| Immunogen | : | Human epidermal keratin |
| Source | : | Mouse |
| Specificity | : | Cytokeratin |
| Protocol | : | 30 min @ RT |
| Tissue type | : | FFPE |
| Control tissue | : | SKIN |
| Pretreatment | : | Trypsin, 37°C, 20 min |
| Intended Use | : | IVD |
Human cytokeratins (40 kD to 68 kD) are a family of water-insoluble proteins that form a major part of the cytoskeleton of epithelial cells. Immunohistochemical analysis of a large variety of neoplasms has established keratin protein immunohistochemistry as an important aid for classification of epithelial neoplasms. Monoclonal antibodies AE1 and AE3 recognize the acidic and basic subfamilies of cytokeratin, respectively. Thus, the combination of these two antibodies can be used to detect almost all human epithelia. These antibodies show no cross-reactivities with other cytoskeletal proteins. This monoclonal antibody cocktail can be used to detect almost all human epithelia. Membrane and cytoplasmic staining is seen in epithelial cells.
