ER alpha
Breast Carcinoma tissue Stained with Anti-ER alpha using DAB chromogen
| Clone | : | EPR703(2) |
| Isotype | : | IgG |
| Immunogen | : | A synthetic peptide corresponding to residues on the C- terminus of human ERalpha |
| Source | : | Rabbit |
| Specificity | : | ER-Alpha |
| Protocol | : | 30 min @ RT |
| Tissue type | : | FFPE |
| Control tissue | : | Fibro adenoma (Breast) tissue |
| Pretreatment | : | AR Citra Plus |
| Intended Use | : | IVD |
Estrogen receptor alpha (ER alpha) is a nuclear protein and member of the steroid hormone receptor family. ER alpha possesses both DNA binding and ligand binding domains, and exerts a significant role in activating the transcription of certain genes. Ligand-dependent dimerization and phosphorylation both function to regulate the transcriptional activation of ER alpha. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to Antiestrogen (e.g. tamoxifen) therapy.
