Mast Cell Tryptase
Mast cell in the dermis highlighted by Mast Cell Tryptase antibody.
| Clone | : | AA1 |
| Isotype | : | IgG1 |
| Immunogen | : | Human Mast Cell Tryptase purified from human lung tissue |
| Source | : | Mouse |
| Specificity | : | Mast Cell Tryptase antigen |
| Protocol | : | 30 min @ RT |
| Tissue type | : | FFPE |
| Control tissue | : | SKIN |
| Pretreatment | : | None |
| Intended Use | : | IVD |
The monoclonal antibody produced by clone AA1 reacts with human mast cell tryptase in different tissues. Relatively high levels of the enzyme are found in mast cells of skin and lung. Tryptase, a structurally unique trypsin like serine protease, is a biochemical marker that has proven useful for disorders that involve systemic mast cell activation. It is shown to be implicated as a potential mediator in the pathology of several mast cell related allergic and inflammatory conditions, including rhinitis, conjunctivitis, and most notably asthma. This antibody stains Mast Cell tryptase antigen in cytoplasm of mast cells in skin, lung and tonsil tissues
