Mesothelin
Ovary tissue stained with anti-Mesothelin using AEC Chromogen
| Clone | : | 5B2 |
| Isotype | : | IgG1 |
| Immunogen | : | Prokaryotic recombinant fusion protein corresponding to approximately 100 amino acids from membrane bound form of mesothelin. |
| Source | : | Mouse |
| Specificity | : | Mesothelin |
| Protocol | : | 30 min @ RT |
| Tissue type | : | FFPE |
| Control tissue | : | OVARY CYST ADENOCARCINOMA |
| Pretreatment | : | AR-10 |
| Intended Use | : | IVD |
Mesothelin, a 40kD glycosyl-phosphatidylinositol-linked cell surface glycoprotein, is present on the surface of the mesothelial cells and may be involved in cell adhesion. It is also seen on mesotheliomas, epithelial ovarian cancers, and some squamous cell carcinomas. Clone 5B2 reactivity has been seen in epitheloid mesotheliomas and adenocarcinomas of lung, ovary, peritoneum, endometrium, pancreas, stomach and colon to a varying degree. Mesothelin is abundant in normal mesothelial cells from which malignant mesotheliomas and ovarian cystadenocarcinomas are derived. This antibody can be used in conjunction with antibody to calretinin for evaluation of mesotheliomas.
