Mucin-2 (MUC-2)
Colon Carcinoma stained with anti-Mucin-2 using AEC Chromogen
| Clone | : | CCP58 |
| Isotype | : | IgG1 |
| Immunogen | : | Synthetic human MUC-2 (MI-29) peptide (VNTR region) |
| Source | : | Mouse |
| Specificity | : | MUC-2 |
| Protocol | : | 30 min @ RT |
| Tissue type | : | FFPE |
| Control tissue | : | COLON or COLON CARCINOMA |
| Pretreatment | : | AR-10 |
| Intended Use | : | IVD |
Mucins are a group of high molecular weight, highly glycosylated proteins expressed in normal and carcinogenic colon. MUC-2 is a 520-kD glycoprotein of the gastrointestinal tract. The core of the glycoprotein consists of a variable number of tandem repeats of a 23 amino acid sequence. Mucin-2 is found in normal epithelial cells of the colon or in colon carcinoma. Muc-2 glycoprotein is expressed in mucinous tumors but not in serous tumors. This antibody reacts with Mucin-2 (MUC-2) protein, amino acid sequence GTQTP and does not react with MUC-1, MUC-3, or human milk fat globule membranes. This antibody stains positive for colon gastric cancer cells, normal intestine, colon and salivary glands, and some human colon carcinoma cell lines (LS174T). This antibody localizes Mucin-2 (MUC-2) protein in cytoplasm
