International Blog

i6000 – the workhorse of a pathology lab! - (Interface for both clinical and research diagnostics)

When it comes to cancer diagnostics, tissue-based staining is still the gold standard of diagnostic workflow. And when there are thousands of cancer patients – worldwide - waiting eagerly for “their life and death question”, there is no luxury of time! Everyday there could be hundreds of samples waiting to be tested – and so some form of automation and high-throughput becomes mandatory.

Enter the semi-automatic workhorse of cancer diagnostics – the BioGenex i6000TM system. The BioGenex i6000 Elite Dx is a semi-automated, high-throughput, multiplex IHC system that is flexible, efficient and value for the bucks!

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EZ-AR2 Elegance – All-in-One and All-at-Once Antigen Retrieval solution

Antigen Retrieval:

Antigen retrieval is an effective method of unmasking antigenic epitopes on the surface of formalin-fixed paraffin-embedded (FFPE) tissue sections. The antigen retrieval technique breaks the methylene bridges between epitopes and unrelated proteins to expose antigenic sites for antibody binding (1). BioGenex Laboratories Inc. invented the reverse epitope masking method in 1991 (2), with this assay now being routinely practiced in laboratories throughout the world. For in-depth article on Antigen Retrieval click here.

EZ-AR2 Elegance Antigen Retrieval Solution:

BioGenex EZ-AR2 Elegance is the first universal one-step solution for preparation of formalin-fixed paraffin-embedded (FFPE) tissue sections for IHC staining. The high throughput system is designed to perform de-wax, rehydration, and antigen retrieval all in one simple step. EZ-AR2 Elegance buffer together with EZ-Retriever® processes about 100 slides in less than 30 minutes. Efficient antigen retrieval allows higher dilution of antibodies and shortens incubation times for many antibodies – cost-effective and saves time!

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EZ-Retriever® + EZ-AR™ Elegance solution - Features and Benefits

EZ-Retriever® System:


Antigen Retrieval
- invented by BioGenex - is an effective method of unmasking antigenic epitopes in formalin-fixed paraffin-embedded tissue sections (FFPE) by heating in microwave using specially formulated Antigen Retrieval solutions. The Antigen Retrieval technique breaks the formalin induced cross-linking of proteins, allowing access of antigenic epitopes. Covered by patents issued to BioGenex, this method has been practiced in laboratories throughout the world.

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New Treatment for Urothelial Cancer - BioGenex International

Apr 21, 2016

Urothelial Carcinoma (UCC, also known as transitional cell carcinoma) is a cancer that starts in the urothelial cells, which line the inside of the bladder and other parts of the urinary tract. According to the American Cancer Society there were over 76,000 new cases of bladder cancer diagnosed and over 15,000 deaths from advanced bladder cancer in the United States in 2014. At stage I, the 5-year survival rate is about 88% but at stage IV, the 5-year survival rate falls to 15%. Poor prognosis and ineffective therapies for patients with advanced bladder cancer make the discovery of new drugs very important for the treatment of this common disease.

In a pioneering study published last month in Molecular Cancer Therapeutics, researchers at Agensys Inc. identified the SLITRK6 protein as a new UCC biomarker and developed a novel antibody-drug conjugate (ADC) targeting SLITRK6 for the treatment of metastatic bladder cancer. Recent advances in the antibody-drug conjugate (ADC) technology and two recently approved ADCs have brought this drug class to the forefront of drug development in oncology.

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