BioGenex, a pioneer in automated staining solution provider for cancer diagnostics announces the launch of eleven new primary antibodies for cancer immunohistochemistry (IHC). With our Super Sensitive Detection System, our IHC solution offers the widest portfolio with over 400 primary antibodies, reagents, consumables, and ancillaries.
Included in the launch are
Anti-CD45, Clone 2B11 & PD7/26
CD45 monoclonal antibody (anti-leukocyte common antigen) is routinely used to aid the differential diagnosis of undifferentiated neoplasms, whenever malignant lymphoma is suspected by the morphological or clinical data. This antibody is expressed almost exclusively by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes as well as plasma cell precursors. Find out more about anti-CD45.
Anti-Cytokeratin 7, Clone KRT7/760
Cytokeratin 7 is an intermediate filament protein (IFP) of 54 kDa that recognizes the simple epithelium found in most glandular and transitional epithelia. This rabbit monoclonal antibody is highly specific to cytokeratin 7 and shows no cross-reaction with other IFP. Find out more about anti-cytokeratin 7.
Anti-Cytokeratin 20, Clone KRT20/1992
This monoclonal antibody recognizes an intermediate filament protein cytokeratin 20 (KRT20, CK20) which is abundantly expressed in goblet cells and enterocytes of the gastrointestinal tract. CK20 plays a significant role in maintaining keratin filament organization in intestinal epithelia and can be used as a marker of pancreatic, colorectal cancer, adenocarcinomas of the colon, stomach, and biliary tract. Find out more about anti-cytokeratin 20.
Anti-CD20/MS4A1, Clone IGEL/773
The CD20 is a non-Ig differentiation antigen of B cells and its expression is restricted to normal and neoplastic B cells. Anti-CD20 can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood, and B cell localization in tissues. Find out more about anti-CD20/MS4A1.
Anti-GCDFP-15, Clone PIP/1571
Gross cystic disease fluid protein-15 (GCDFP-15) monoclonal antibody recognizes GCDFP-15 protein of 15 kDa, a common marker of breast cancer. GCDFP-15, also known as prolactin-inducible protein (PIP) is a prolactin and androgen controlled protein. This antibody can be used in the identification of metastatic breast cancer or fluid analysis.
Find out more about anti-GCDFP-15.
Anti-CD30, Clone EPR4102
CD30 functions as a receptor for TNFSF8/CD30L and may play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Anti-CD30 monoclonal antibody distinguishes large cell lymphomas derived from activated lymphoid cells from histocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. Find out more about anti-CD30.
Anti-HCGα, Clone HCGα/53
Human chorionic gonadotropin (HCG), secreted by normal trophoblasts is composed of two non-identical, non-covalently linked polypeptide chains such as the α and β subunits. Anti-HCGα reacts with a protein of aproximately13 kDa identified as α sub-unit of HCG. Find out more about anti-HCGα.
Anti-CD3e, Clone C3e/1931
CD3e is a part of T cell receptor-CD3 (TCR-CD3) complex present on T-lymphocyte cell surface that plays an essential role in the adaptive immune response. CD3e plays an essential role in correct T-cell development. Reportedly, the CD3 complex is involved in signal transduction to the T-cell interior following antigen recognition.
Find out more about anti-CD3e.
Anti-c-Jun, Clone 4H9
c-Jun is a known proto-oncogene and is found to be significantly overexpressed in lung and breast cancers, making it a viable tumor marker. c-Jun antibodies are used to study the signal-transducing transcription factor of the AP1 family. c-Jun has been implicated in several areas of cell biology including cell cycle progression, transformation, differentiation and apoptosis.
Find out more about anti-c-Jun.
Anti-BOB-1, Clone SP92
The BOB-1 / OBF-1 / OCA-B protein is a B-cell specific co-activator of the Oct1 and Oct2 transcription factors. BOB-1 facilitates transactivation of immunoglobulins and other B-cell specific genes through the binding and activation of the transcription factors Oct-1 and Oct-2. Find out more about anti-BOB-1.
Anti- CNPase (Myelin), Clone SMI 91
CNPase expression is seen in myelin-producing cells, including oligodendrocytes and Schwann cells. Since the enzyme is a myelin-associated enzyme, it is of considerable interest in the study of diseases and disorders in which myelin is affected such as multiple sclerosis, subacute sclerosing panencephalitis, acquired immunodeficiency with CNS involvement, and peripheral neuropathies. Find out more about anti- CNPase (Myelin).
BioGenex is offering these new antibodies in different formats: - ready-to-use (RTU) vials for manual staining and bar-coded vials for the i6000® and Xmatrx® family of automated staining systems. They are also available in concentrated format along with the antibody diluent (#HK156) and are also compatible with third-party detection systems.
“Introduction of these antibodies for cancer diagnostics demonstrates our commitment towards ‘Accelerating the Pace of Precision Medicine’. We are determined and will continue to bring quality products to our customers,” said Krishan Kalra Ph.D. CEO of BioGenex.
About BioGenex Laboratories
BioGenex designs develop and commercialize fully-automated molecular pathology systems for cancer diagnosis, prognosis, personalized medicine, and life science research. Our fully-automated workstations are the most in-depth systems available globally. Our customer-focused approach, with excellent technical and customer support provides a unique and powerful service for pathology labs. Our spirit of innovation drives us to deliver cutting edge technology, years ahead of our competition, and the finest systems for Life Science research and diagnostics.