BioGenex, a pioneer in automated staining solution provider for cancer diagnostics announces the launch of five new primary antibodies for cancer immunohistochemistry (IHC). This in addition to the recently announced launch, has expanded the growing list of primary antibodies in BioGenex catalog. With our Super Sensitive Detection System, our IHC solution offers the widest portfolio with over 400 primary antibodies, reagents, consumables, and ancillaries.
Included in this launch are
Pituitary growth hormone (GH) plays a crucial role in stimulating and controlling the growth, metabolism, and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membrane-bound receptor and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Anti-GH is a useful marker in the classification of pituitary tumors and the study of pituitary disease (acromegaly).
Find out more about Anti-GH.
This antibody recognizes a 47-55 kDa tumor suppressor protein, identified as Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilm's tumors. WT1, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous and is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm's tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. WT1 protein expression in mesothelial cells has become a reliable marker for the diagnosis of mesotheliomas.
Find out more about Anti-WT1.
Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. Mutations in this gene cause congenital fibrosis of the type 3 extraocular muscles. TUBB3 can be also used as a predictive and prognostic marker in various tumors.
Find out more about Anti-Tubulin β3.
Protein phosphorylation is a fundamental event in the regulation of a large number of intracellular processes. Phosphorylation of specific tyrosine residues is the result of activation or stimulation of their respective protein tyrosine kinases. The phosphorylated proteins can be auto-phosphorylated kinases or certain cellular protein substrates. Tyrosine-phosphorylated proteins are involved in signal transduction and in the regulation of cell proliferation. Antibody to phosphotyrosine provides an excellent tool for the detection, characterization, and purification of phosphotyrosine containing proteins. Anti-P-Tyr monoclonal shows no cross-reaction with other phosphoamino acids and is used in multiple applications including staining of formalin/paraffin tissues.
Find out more about Anti-P-Tyr.
Anti-Ferritin Light chain
Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Mammalian ferritins consist of 24 subunits made up of 2 types of polypeptide chains: ferritin heavy chain and ferritin light chain. Ferritin heavy chains catalyze the first step in iron storage - the oxidation of Fe (II); whereas ferritin light chains promote the nucleation of ferrihydrite; enabling storage of Fe (III). Light chain ferritin is involved in cataracts by at least two mechanism (hereditary hyperferritinemia cataract syndrome) in which light chain ferritin is overexpressed in serum and tissues. Find out more about Anti-Ferritin Light chain.
BioGenex is offering these new antibodies in different formats: - ready-to-use (RTU) vials for manual staining and bar-coded vials for the i6000® and Xmatrx® family of automated staining systems. They are also available in concentrated format along with the antibody diluent (#HK156) and are also compatible with third-party detection systems.
“Introduction of these antibodies for cancer diagnostics demonstrates our commitment towards ‘Accelerating the Pace of Precision Medicine’. We are determined and will continue to bring quality products to our customers,” said Krishan Kalra Ph.D. CEO of BioGenex.
About BioGenex Laboratories
BioGenex designs develop and commercialize fully-automated molecular pathology systems for cancer diagnosis, prognosis, personalized medicine, and life science research. Our fully-automated workstations are the most in-depth systems available globally. Our customer-focused approach, with excellent technical and customer support provides a unique and powerful service for pathology labs. Our spirit of innovation drives us to deliver cutting edge technology, years ahead of our competition, and the finest systems for Life Science research and diagnostics.