Research Platforms

BioGenex is a pioneer in the design, development and manufacturing of advanced systems for automation of cell and tissue-based staining. The Xmatrx research systems (NANO, MINI and Infinity) are the direct result of our platform technology innovation. They offer a variety of automation, throughput and assay applications for translational and clinical research. Our key technology differentiators, including the eXACT temperature control and reaction micro-chamber, enable any slide-based assays such as immunohistochemistry (IHC), in situ hybridization (ISH), fluorescence in situ hybridization (FISH), immuno-fluorescence (IF), co-detection and multiplex applications (double and triple stains; IHC/ISH), in situ PCR, micro-RNA and special staining.

The i6000™ Infinity is a high-throughput open-system platform for IHC and Special-Stain staining with a capacity of 200 slides in 8 hours using BioGenex protocols. The system is supplied together with the EZ-Retriever®, for microwave-based dewaxing and antigen retrieval. The Xmatrx® and i6000 platforms meet globally accepted quality standards (ISO13485:2003 & ISO9001:2008), improve laboratory workflow, productivity and reproducibility, and are intended for clinical research (RUO) in the US.

1. Xmatrx® Infinity:

Features & Benefits:

  • Intelligent and flexible system offering infinite possibilities – IHC, IF ISH, FISH, CISH, IF, Multiplexing and in situ PCR.
  • Simultaneous optimization of up to 40 parameters in single run
  • Reaction micro-chamber reduces micro-reagent consumption by up to 90%
  • 40 independent thermocyclable (PCR) workstations
  • Intuitive software designed for ease of use and flexibility
  • Reports for inventory management and regulatory compliance
  • Multiple slide processing options – Random, Continuous and STAT

2. NanoVIP:

Features & Benefits:

  • All-in-One – FISH, in situ PCR and ISH
  • Add micro-reagents manually to save cost
  • Intelligent SMS alerts for manual intervention steps
  • Economical and affordable
  • Flexible open system software - to create, edit and save protocols for future use
  • Run 10 different protocols simultaneously


3. Xmatrx® MINI:

Features & Benefits:

  • in situ PCR and FISH Work Station
  • Hybridizer with eXACT™ temperatures
  • 10 independent thermal cyclers
  • Built-in touch screen display for easy operations
  • On-board wash with effective waste drainage system
  • Audio-visual alerts at every step for manual intervention
  • User-friendly software with ability to add or delete cycles, store protocols for future use and perform up to 45 PCR cycles


4. i6000™ Infinity:

Features & Benefits:

  • Multi-functional System for IHC, IF and Special Stains
  • Fully open system to customize any manual protocol
  • High capacity: 60 slides and 53 antibodies per run
  • Works seamlessly with EZ-Retriever® for Eco-friendly De-waxing, Rehydration and Antigen Retrieval
  • Reagent dispense volumes: 100 μL to 900 μL
  • Liquid level sensor for accurate reagent dispensing
  • Audio-visual alerts at every step for manual intervention
  • Multiple slide processing options – Random, Continuous and STAT



5. EZ-Retriever® System:

Programmable Microwave oven with built in temperature controlEZ-Retriever

Greater reproducibility Dewaxing, Rehydration, and Antigen Retrieval
  • Preserved tissue morphology with fast uniform heating & cooling of AR solutions
  • High Throughput - 96 Slides / 35 minutes
  • Optimized factory protocols for convenience and consistent results
  • AR solutions are non-hazardous, non-flammable and odorless
  • Compliance to CLSI (Clinical and Laboratory Standards Institute) guidelines


Specifications Xmatrx® Ultra Rx Xmatrx® Infinity i6000™ Infinity
Automation Full (baking through cover slip) Full (baking through cover slip) Automated staining
Run Time (full slide load) Open System / User defined Open System / User defined Open System / User defined
Temperature Range Ambient to 105 oC Ambient to 105 oC NA
Reagent Dispensing Volume 10-850 µl 10-850 µl 100-1000 µl
Slide Capacity 40 40 60
Reagent Capacity 42 49 60
Bar Code Reader NA NA NA
Bulk Reagent Carboy 7 x 4 L 7 x 4 L 2 x 10 L
Waste Container 20 L 8 L 20 L
Auto Drain NA NA
Languages enabled English English English, Chinese, German
LIMS - enabled data tracking and management
Ease of slide loading NA NA
Protocols Template / Self Template / Self Template / Self
Dimensions (D/W/H) 30”/43”/54” 29”/46”/59” 24”/40.5”/18.5”
Weight 400 lb/ 182 kg 400 lb/ 182 kg 130 lb / 59 kg
Research Platforms /Application IHC ISH/ CISH Double Staining Special Stains FISH IF miRNA ISH

Multiplexing (ISH + IHC)

In Situ PCR
Xmatrx® Infinity
Xmatrx® Ultra Rx
i6000TM Infinity
Research Platforms