Research Platforms

BioGenex is a pioneer in the design, development and manufacturing of advanced systems for automation of cell and tissue-based staining. The Xmatrx research systems (NANO, MINI and Infinity) are the direct result of our platform technology innovation. They offer a variety of automation, throughput and assay applications for translational and clinical research. Our key technology differentiators, including the eXACT temperature control and reaction micro-chamber, enable any slide-based assays such as immunohistochemistry (IHC), in situ hybridization (ISH), fluorescence in situ hybridization (FISH), immuno-fluorescence (IF), co-detection and multiplex applications (double and triple stains; IHC/ISH), in situ PCR, micro-RNA and special staining.

The i6000™ Infinity is a high-throughput open-system platform for IHC and Special-Stain staining with a capacity of 200 slides in 8 hours using BioGenex protocols. The system is supplied together with the EZ-Retriever®, for microwave-based dewaxing and antigen retrieval. The Xmatrx® and i6000 platforms meet globally accepted quality standards (ISO13485:2003 & ISO9001:2008), improve laboratory workflow, productivity and reproducibility, and are intended for clinical research (RUO) in the US.

1. Xmatrx® Infinity:

Features & Benefits:

Intelligent and flexible system offering infinite possibilities – IHC, IF ISH, FISH, CISH, IF, Multiplexing and in situ PCR.
Simultaneous optimization of up to 40 parameters in single run
Reaction micro-chamber reduces micro-reagent consumption by up to 90%
40 independent thermocyclable (PCR) workstations
Intuitive software designed for ease of use and flexibility
Reports for inventory management and regulatory compliance
Multiple slide processing options – Random, Continuous and STAT

2. NanoVIP:

Features & Benefits:

All-in-One – FISH, in situ PCR and ISH
Add micro-reagents manually to save cost
Intelligent SMS alerts for manual intervention steps
Economical and affordable
Flexible open system software - to create, edit and save protocols for future use
Run 10 different protocols simultaneously

3. Xmatrx® MINI:

Features & Benefits:

in situ PCR and FISH Work Station
Hybridizer with eXACT™ temperatures
10 independent thermal cyclers
Built-in touch screen display for easy operations
On-board wash with effective waste drainage system
Audio-visual alerts at every step for manual intervention
User-friendly software with ability to add or delete cycles, store protocols for future use and perform up to 45 PCR cycles

4. i6000™ Infinity:

Features & Benefits:

Multi-functional System for IHC, IF and Special Stains
Fully open system to customize any manual protocol
High capacity: 60 slides and 53 antibodies per run
Works seamlessly with EZ-Retriever® for Eco-friendly De-waxing, Rehydration and Antigen Retrieval
Reagent dispense volumes: 100 μL to 900 μL
Liquid level sensor for accurate reagent dispensing
Audio-visual alerts at every step for manual intervention
Multiple slide processing options – Random, Continuous and STAT

5. EZ-Retriever® System:

Programmable Microwave oven with built in temperature control

Greater reproducibility Dewaxing, Rehydration, and Antigen Retrieval

Preserved tissue morphology with fast uniform heating & cooling of AR solutions
High Throughput - 96 Slides / 35 minutes
Optimized factory protocols for convenience and consistent results
AR solutions are non-hazardous, non-flammable and odorless
Compliance to CLSI (Clinical and Laboratory Standards Institute) guidelines

Specifications	Xmatrx® Ultra Rx	Xmatrx® Infinity	i6000™ Infinity
Automation	Full (baking through cover slip)	Full (baking through cover slip)	Automated staining
Run Time (full slide load)	Open System / User defined	Open System / User defined	Open System / User defined
Temperature Range	Ambient to 105 oC	Ambient to 105 oC	NA
Reagent Dispensing Volume	10-850 µl	10-850 µl	100-1000 µl
Slide Capacity	40	40	60
Reagent Capacity	42	49	60
Bar Code Reader	NA	NA	NA
Bulk Reagent Carboy	7 x 4 L	7 x 4 L	2 x 10 L
Waste Container	20 L	8 L	20 L
Auto Drain	✓	NA	NA
Languages enabled	English	English	English, Chinese, German
LIMS - enabled data tracking and management	✓	✓	✓
Auto DAB	✓	NA	NA
Ease of slide loading	✓	NA	NA
Protocols	Template / Self	Template / Self	Template / Self
Dimensions (D/W/H)	30”/43”/54”	29”/46”/59”	24”/40.5”/18.5”
Weight	400 lb/ 182 kg	400 lb/ 182 kg	130 lb / 59 kg

Research Platforms /Application	IHC	ISH/ CISH	Double Staining	Special Stains	FISH	IF	miRNA ISH	Multiplexing (ISH + IHC)	In Situ PCR
Xmatrx® Infinity	✓	✓	✓	✓	✓	✓	✓	✓	✓
Xmatrx® Ultra Rx	✓	✓	✓	✓	✓	✓	✓	✓	✓
i6000^TM Infinity	✓	NA	✓	✓	NA	✓	NA	NA	NA

Infinity

NANO

MINI

i6000 Elite Rx

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