Research Platforms

BioGenex is a pioneer in the design, development and manufacturing of advanced systems for automation of cell and tissue-based staining. The Xmatrx research systems (NANO, MINI and Infinity) are the direct result of our platform technology innovation. They offer a variety of automation, throughput and assay applications for translational and clinical research. Our key technology differentiators, including the eXACT temperature control and reaction micro-chamber, enable any slide-based assays such as immunohistochemistry (IHC), in situ hybridization (ISH), fluorescence in situ hybridization (FISH), immuno-fluorescence (IF), co-detection and multiplex applications (double and triple stains; IHC/ISH), in situ PCR, micro-RNA and special staining.

The i6000 Elite Rx is a high-throughput open-system platform for IHC and Special-Stain staining with a capacity of 200 slides in 8 hours using BioGenex protocols. The system is supplied together with the EZ-Retriever®, for microwave-based dewaxing and antigen retrieval. The Xmatrx and i6000 platforms meet globally accepted quality standards (ISO13485:2003 & ISO9001:2008), improve laboratory workflow, productivity and reproducibility, and are intended for clinical research (RUO) in the US.

1. Xmatrx Infinity:

Features & Benefits:

Intelligent and flexible system offering infinite possibilities – IHC, IF ISH, FISH, CISH, IF, Multiplexing and in situ PCR.
Simultaneous optimization of up to 40 parameters in single run
Reaction micro-chamber reduces micro-reagent consumption by up to 90%
40 independent thermocyclable (PCR) workstations
Intuitive software designed for ease of use and flexibility
Reports for inventory management and regulatory compliance
Multiple slide processing options – Random, Continuous and STAT

2.Xmatrx Nano VIP:

Features & Benefits:

All-in-One – FISH, in situ PCR and ISH
Add micro-reagents manually to save cost
Intelligent SMS alerts for manual intervention steps
Economical and affordable
Flexible open system software - to create, edit and save protocols for future use
Run 10 different protocols simultaneously

3. Xmatrx Mini:

Features & Benefits:

in situ PCR and FISH Work Station
Hybridizer with eXACT™ temperatures
10 independent thermal cyclers
Built-in touch screen display for easy operations
On-board wash with effective waste drainage system
Audio-visual alerts at every step for manual intervention
User-friendly software with ability to add or delete cycles, store protocols for future use and perform up to 45 PCR cycles

4. i6000 Elite Rx Automated Staining Systems:

Features & Benefits:

Multi-functional System for IHC, IF and Special Stains
Fully open system to customize any manual protocol
High capacity: 60 slides and 53 antibodies per run
Works seamlessly with EZ-Retriever® for Eco-friendly De-waxing, Rehydration and Antigen Retrieval
Reagent dispense volumes: 100 μL to 900 μL
Liquid level sensor for accurate reagent dispensing
Audio-visual alerts at every step for manual intervention
Multiple slide processing options – Random, Continuous and STAT

EZ-Retriever^®

Programmable Microwave oven with built in temperature control

High capacity: 60 slides and 53 antibodies per run. 200 slides in 8 hours
Greater reproducibility Dewaxing, Rehydration, and Antigen Retrieval
Preserved tissue morphology with fast uniform heating & cooling of AR solutions
High Throughput - 96 Slides / 35 minutes
Optimized factory protocols for convenience and consistent results
AR solutions are non-hazardous, non-flammable and odorless
Compliance to CLSI (Clinical and Laboratory Standards Institute) guidelines

Specifications	Xmatrx Ultra Rx	Xmatrx Infinity	i6000 Elite Rx
Automation	Full (baking through cover slip)	Full (baking through cover slip)	Automated staining
Run Time (full slide load)	Open System / User defined	Open System / User defined	Open System / User defined
Temperature Range	Ambient to 105 oC	Ambient to 105 oC	NA
Reagent Dispensing Volume	10-850 µl	10-850 µl	100-1000 µl
Slide Capacity	40	40	60
Reagent Capacity	42	49	60
Bar Code Reader	NA	NA	NA
Bulk Reagent Carboy	7 x 4 L	7 x 4 L	2 x 10 L
Waste Container	20 L	8 L	20 L
Auto Drain	✓	NA	NA
Languages enabled	English	English	English, Chinese, German
LIMS - enabled data tracking and management	✓	✓	✓
Auto DAB	✓	NA	NA
Ease of slide loading	✓	NA	NA
Protocols	Template / Self	Template / Self	Template / Self
Dimensions (D/W/H)	30”/43”/54”	29”/46”/59”	24”/40.5”/18.5”
Weight	400 lb/ 182 kg	400 lb/ 182 kg	130 lb / 59 kg

Research Platforms /Application	IHC	ISH/CISH	Double Staining	Special Stains	FISH	IF	miRNA ISH	Multiplexing (ISH + IHC)	In Situ PCR
Xmatrx® Infinity	✓	✓	✓	✓	✓	✓	✓	✓	✓
Xmatrx® Ultra Rx	✓	✓	✓	✓	✓	✓	✓	✓	✓
i6000^TM Elite RX	✓	NA	✓	✓	NA	✓	NA	NA	NA

Infinity

NANO

MINI

i6000 Elite Rx

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