Anti- Retinoblastoma, Clone 13A10


Retinoblastoma gene / protein. Tumor suppressor gene at 13q14 it Encodes a 110-114 kDa nuclear protein that plays an important role in cell cycle progression by regulating cell cycle arrest at G1-S. Retinoblastoma (Rb) is a rare tumor of retina with mutations at chromosome 13Activation of ATF-2 initiate's expression of TGF-beta2 which in turn inhibits transcription of genes affecting cell growth. Bilateral mutation of the Rb gene may play a role in the development of malignant tumors.
Intended Use: IVD
Antibody Type: Monoclonal
Clone: 13A10
Source: Mouse
Tissue Type/Cancer Type: Tonsil tissue